Computational Biologist
Apply Job ID 38615 Date posted 04/18/2026Job Family:
Scientific Research & Analysis
Travel Required:
Clearance Required:
What You Will Do:
We are seeking a Biologist to support research on laboratory and computational analysis of genomic and epigenomic data. The work supports ongoing research involving genotyping, long-range sequencing, and DNA methylation profiling. This is a full-time opportunity located in Baltimore, MD.
Responsibilities:
Perform DNA extraction from blood, tissue, or cultured cells using established protocols.
Conduct genotyping assays (e.g., SNP arrays, PCR-based methods.
Support long-range sequencing workflows (e.g., library prep and sequencing using long-read platforms such as PacBio or Oxford Nanopore).
Provide technical support for biological research by assisting in the study of fundamental principles of plant and animal life, including sample quality, integrity, coverage, and contamination assessment.
Evaluate biological data and quality control metrics, flag anomalies, and provide preliminary interpretations to research staff.
Perform basic laboratory experiments, including DNA methylation assays (e.g., bisulfite conversion and array‑ or sequencing‑based methods), following established protocols.
Execute and support quality control pipelines for sequencing and genotyping data; compile, document, and maintain QC metrics in standardized formats.
Conduct data analysis using established tools and methods, including R for statistical analysis and visualization and scripting languages (e.g., Python, Bash) for pipeline support.
Modify and adapt existing scripts and analytical pipelines to meet project‑specific requirements and support data integration efforts.
Prepare, organize, and maintain laboratory samples, supplies, and equipment, ensuring accurate laboratory records, notebooks, and electronic documentation.
Prepare summary tables, figures, and written descriptions of methods and results; present findings in internal meetings and contribute to draft reports, manuscripts, and project updates.
What You Will Need:
Master’s degree
Minimum of FOUR (4) years of experience in biology or a related field performing biological research functions in a research setting.
R/Python/Bash scripts experience.
Experience modifying, maintaining, or executing existing analysis scripts and pipelines to support project‑specific research needs.
Experience compiling QC metrics, maintaining accurate laboratory notebooks and electronic records, and preparing summary tables, figures, and written descriptions of methods and results
Experience identifying routine technical issues, applying standard troubleshooting approaches, and learning new laboratory or analytical techniques as required
Must be able to obtain and maintain a Federal or DoD Public Trust. Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse. Candidates with an active Public Trust or existing suitability are preferred.
What Would Be Nice To Have:
Proficiency in one scripting language
Familiarity with genomic data formats (FASTQ, BAM, VCF)
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
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