Bioinformatics Scientist
Apply Job ID 41206 Date posted 06/26/2026Job Family:
Scientist
Travel Required:
Clearance Required:
What You Will Do:
We are seeking a Bioinformatics Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through analysis of short-and long-read sequencing data, including bulk and single-cell transcriptomic workflows. The ideal candidate has a relevant scientific or technical background, proficiency in Python and R, and experience with command line environments, high-performance computing resources, and messenger ribonucleic acid (RNA) sequencing data. This is a full-time, on-site opportunity in Bethesda, MD.
- Perform computational analysis of deep sequencing data, including short-read and long-read platforms.
- Conduct transcriptomic data analyses including alignment, abundance estimation, differential gene expression, and gene ontology/pathway analysis from bulk and single-cell workflows.
- Maintain proper and detailed documentation of analyses performed and report results at laboratory meetings.
- Provide programming and troubleshooting support to the Federal Government in the dissemination of research data.
- Perform computational analyses on research datasets.
- Collaborate with scientists to design, analyze, manage, and interpret data.
- Recommend appropriate computational tools for testing scientific hypotheses and drawing valid conclusions.
- Record observations and present findings at weekly laboratory meetings.
- Attend scientific and programming meetings; take detailed notes and compile organized reports.
- Maintain organized laboratory notebooks or databases to record computational results.
- Provide statistical support and analysis on research data.
- Write complex queries across multiple databases.
- Contribute to scientific manuscripts and publications.
What You Will Need:
- Bachelor’s degree in Biology, Computer Science, Mathematics, or a related discipline.
- A minimum of ONE (1) years of bioinformatics, computational biology, or related experience.
- Proficiency in Python and R programming languages.
- Experience working in command line environments (Unix/Linux).
- Experience utilizing high-performance computing (HPC) resources.
- Experience analyzing messenger RNA sequencing (mRNA-seq) data.
- Strong analytical, data management, and problem-solving skills.
- Ability to collaborate effectively with multidisciplinary scientific teams.
- Strong written and verbal communication skills.
- Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
What Would Be Nice To Have:
- Experience working with single-cell sequencing data and advanced transcriptomics workflows.
- Experience contributing to scientific publications or manuscripts.
- Familiarity with federal research environments such as NIH or similar institutions.
- Knowledge of database management and advanced query development.
- Exposure to additional bioinformatics tools and pipelines beyond Python and R.
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.
All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.
If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.
Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.
