Electron Microscope Scientist

Job Family:

Scientist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are looking for an Electron Microscope Scientist to support the Vaccine Research Center (VRC) at NIAID by overseeing cryo-electron microscopy operations and supporting structural biology research. This is a full-time position located in Bethesda, MD.

• Provide scientific, technical, and operational oversight of the cryo-EM facility.
• Support structural biology research through high-quality cryo-EM data acquisition and analysis.
• Manage facility operations, including instrument performance, user access, and workflow optimization.
• Oversee operation, maintenance, and troubleshooting of cryo-EM instrumentation.
• Perform cryo-EM sample preparation, data collection, and computational analysis.
• Train and support users, including students, postdocs, and senior scientists.
• Collaborate with NIH investigators and provide guidance on experimental design.
• Develop and implement standardized workflows, SOPs, and best practices.
• Monitor project timelines, instrument usage, and overall facility performance.

What You Will Need:

• Ph.D. in Biology or a closely related field.
• A minimum of THREE (3) years of experience in cryo-electron microscopy, structural biology, or related research.
• Demonstrated expertise in cryo-EM workflows, instrumentation, and facility operations.
• Experience with cryo-EM data collection, processing, and analysis.
• Ability to maintain, calibrate, and troubleshoot advanced microscopy instrumentation.
• Strong organizational, project management, and multitasking skills.
• Ability to support and train a diverse scientific user base.
• Strong collaboration, communication, and leadership skills.
• Proficiency with Microsoft Office Suite and scientific data tools.
• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Background supporting shared scientific core facilities or user-based research environments.
• Familiarity with high-throughput cryo-EM data collection and automation tools.
• Exposure to negative-stain EM workflows and complementary imaging techniques.
• Ability to optimize workflows for improved throughput, reproducibility, and data quality.

The annual salary range for this position is $74,000.00-$124,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com.  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.