Scientific Program Analyst
Apply Job ID 31185 Date posted 08/01/2025Job Family:
Scientific Research & Analysis (Digital)
Travel Required:
Clearance Required:
What You Will Do:
• Advance vaccine and therapeutic protein candidates including monoclonal antibodies, recombinant proteins, and virus-like particles for preclinical development programs.
• Provide continual support for generation and evaluation of recombinant CHO cell lines using automated platforms for clone selection and screening.
• Participate in cell line development platform design, optimization, and cycle-time reduction studies including:
- methods for clone selection, expansion, ranking, and characterization by reviewing recent literature and new technologies with a focus on developing and implementing a stable cell line generation platform in 293 host cells.
- Design and test multiple expression vector configurations.
• Independently plan and execute small-scale process development studies using various culture vessels including tissue culture plates, shake flasks, and small-scale bioreactors.
• Contribute to expression vector design and optimization studies utilizing knowledge of molecular biology techniques.
• Identify, propose, and execute process and procedural changes to improve process performance, robustness, productivity, and efficiency.
• Participate in and lead projects as part of the VPP rapid response initiative towards improved pandemic preparedness.
• Prepare plasmid DNA using standard molecular cloning techniques.
• Perform transfection, selection, and maintenance of cells expressing proteins of interest.
• Generate, maintain and review accurate daily records of experiments and results in a laboratory notebook.
• Prepare and review experimental plans, proposals, reports, SOPs, and production records.
• Collect information, draft and verify data for CMC sections of pre-IND and IND documents to ensure successful registration of candidates.
• Review experiments in order to evaluate the progress of the research and ensure that experiments and documentation conform to established protocols.
• Work closely with other members of CLD team, upstream process development and downstream process development teams to improve workflow efficiency and overall process yield.
• Ensure timely completion of lab cleaning, equipment maintenance, and supply ordering by team members.
• Work collaboratively with team members to develop and establish new techniques and recommend alternative approaches and potential solutions to challenges observed during the cell line development process.
• Lead the design and execution of development projects.
• Coach team members through project planning and writing an experimental plan
• Review and edit the experimental plan
• Support the execution of the experimental plan and review of the data
• Assist team members with preparation of a presentation or other documentation of results
• Work with Federal Task Leader to manage project timelines and provide regular updates to project teams for multiple clonally derived cell line projects running in parallel.
• Present research findings in team meetings, project meetings, and department meetings.
• Coordinate team meeting updates and presentations.
What You Will Need:
• Ph.D. in Biological Sciences with a minimum of 2 years of independent research experience in an academic or industrial setting or M.S. in Biological Sciences with a minimum of 4 years of experience.
• Expertise in cell engineering, aseptic technique and mammalian cell culture along with supporting technologies for cell line engineering including cell counting, high-throughput transfection, single-cell cloning, and flow cytometry.
• Hands-on experience with molecular cloning methods, PCR, and agarose gel electrophoresis.
• Ability to independently design experiments and work plans and manage project timelines for complex projects.
• Demonstrated ability to troubleshoot and complete projects independently.
• Experience leading cell line development projects for monoclonal antibody and/or vaccine production and managing multiple project timelines.
What Would Be Nice To Have:
• Experience writing and editing technical reports and standard operating procedures, and preparing data presentations.
• Ability to work in a collaborative environment within the cell line development team and with other teams.
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
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