Scientist

Job Family:

Scientist (Digital)

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:
We are currently searching for a Scientist to provide support services to satisfy the overall operational objectives of the National Heart, Lung, and Blood Institute. This is a full-time opportunity supporting the office located in Bethesda, MD.

• Develop and oversee research projects aimed at identifying genetic risk factors in the development of myeloid malignancies in sickle cell disease (SCD) patients undergoing curative therapies

• Develop and analyze a mouse model of SCD with p53 mutations to determine the effects of conditioning regimens on clonal hematopoiesis

• Develop and analyze a humanized mouse model to identify clonal driver mutations that confer higher risk of myeloid malignancies

• Lead project aimed at targeting p53 mutated clones using antibody-based conditioning

• Oversee implementation of recommendations, including development of mathematical, analytical, statistical constructs and models.

• Support the development and implementation of comprehensive documentation of modeling approaches and processes.

• Support the establishment, maintenance, and oversight of data governance standards for applicable systems.

• Resolve operational challenges and problems without assistance from senior staff.

• Maintain and prepare animal colony for Animal Protocols.

• Provide scientific and technical expertise to all visiting fellows, post-docs, and technicians. Provide advice and guidance in their day-to-day activities.

• Collaborate with the lab staff in planning, coordinating and reviewing the laboratory’s programs, resources and activities. Participate in the laboratory’s review of future proposals for resource allocations.

• Design and conduct experiments and studies require the application of a broad professional knowledge of scientific theories and principles.

• Evaluate and interpret research results from basic and pre-clinical studies.

• Manage scientific equipment and resources (e.g. reagents, stocks of frozen cells, animal samples) including acquisition, documentation and storage.

• Assist the lab staff in the creation and preparation of a variety of documents required by the lab’s scientific activities (e.g., CRADAs, Material Transfer Agreements, Patent Applications, Animal Protocols, BSC review).

• Review, edit, and as needed, write first drafts of papers, posters and manuscripts produced within the laboratory for consistency of the research agenda, adherence to any applicable scientific policies, and clarity of presentation of data and other scientific information.

What You Will Need:

• Ph.D. in Molecular Science or related field.

• A minimum of SIX (6) years of experience in molecular biology.

• Expertise in generating genetically engineered mouse models of clonal hematopoiesis.

• Strong communication skills, both oral and written.

• Excellent analytical, organizational and time management skills.

• Ability to manage and coordinate high-priority short- and long-term projects and studies in a fast-paced environment.

• Must be able to OBTAIN and MAINTAIN a Federal or DoD "PUBLIC TRUST"; candidates must obtain approved adjudication of their PUBLIC TRUST prior to onboarding with Guidehouse. Candidates with an ACTIVE PUBLIC TRUST or SUITABILITY are preferred.

What Would Be Nice To Have:

• Previous experience with NIH preferred.  

The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com.  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.