Biologist
Apply Job ID 42993 Date posted 08/10/2026Job Family:
Research Scientists (SCI)
Travel Required:
Clearance Required:
What You Will Do:
We are looking for a Biologist to support drug repurposing screening projects, disease model development, assay development, and scientific research activities for the National Center for Advancing Translational Sciences (NCATS). This is a full-time position located in Rockville, MD.
Work with assay providers for assay development and assay transfer to the TDB program.
Perform assay development, optimization, and miniaturization activities.
Conduct high throughput screening using known drugs and bioactive compounds to identify active compounds.
Confirm primary hits and perform secondary and tertiary assays to narrow candidates to top lead compounds.
Perform mechanistic studies to characterize lead compounds when necessary.
Evaluate and apply new technologies and instruments to establish physiologically relevant disease models.
Characterize human induced pluripotent stem cells (iPSCs) and iPSC-derived cells, including developmental marker analysis and disease phenotype studies.
Establish human iPSC-derived cell-based assays for disease modeling.
Lead assay development and compound screening using high-content imaging and flow cytometry assays.
Operate and maintain high throughput flow cytometry instrumentation, including the iQue flow cytometer.
Maintain accurate scientific records and communicate effectively with collaborators and project teams.
Present research findings at internal and external scientific meetings.
Write, submit, and support the publication of scientific manuscripts.
Assist team members with manuscript preparation and revisions.
Collaborate with staff scientists, postdoctoral fellows, IRTA fellows, and external collaborators.
Mentor and train postbaccalaureate IRTA fellows and summer students.
Support the overall operational and scientific objectives of NCATS research programs.
Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer
What You Will Need:
Ph.D. in Molecular, Cell Biology, or Biological Sciences.
Minimum of EIGHT (8) years of experience in flow cytometry assays.
Experience in assay development, high-content imaging assay analysis, compound screening, and lead identification.
Experience with in vitro and in vivo disease model systems.
Proficiency with FlowJo, GraphPad Prism, and Microsoft Office.
Strong oral and written communication skills.
Demonstrated ability to write scientific manuscripts and present scientific data and research findings.
Ability to maintain accurate laboratory documentation and records.
Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
What Would Be Nice To Have:
Background supporting drug repurposing programs.
Ability to work independently and collaboratively in a multidisciplinary research environment.
Hands-on use of high throughput screening platforms and technologies.
Ability to establish disease models using human primary cells or iPSC-derived cells.
Skilled in mentoring junior researchers, fellows, and students.
Collaborative approach with external scientific partners and multidisciplinary project teams.
Scientific publication record in peer-reviewed journals.
Track record presenting research at national or international scientific conferences.
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
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