Human Genomics Program Lead - Software
Apply Job ID 36887 Date posted 02/27/2026Job Family:
Software Development & Support (Digital)
Travel Required:
Clearance Required:
The Program Lead is accountable for defining, shaping, and advancing strategic outcomes for our Human Genomics Program’s software products within the NIH NIAID Bioinformatics and Computational Biosciences Branch (BCBB) portfolio. This role works with our BCBB federal leadership, our intramural research Principal Investigator (PI) stakeholders and within our Science Support and Software Development groups to analyze, propose, and track Program roadmap milestones. The role ensures that roadmap milestones align with BCBB and stakeholder priorities and team capabilities. The role reports on Program progress and proposes resources needed to accomplish proposed milestones.
What You Will Do:
Human Genomics Program Strategic Direction & Vision
Define and maintain a clear Program vision aligned to NIAID and BCBB objectives
Articulate roadmap milestones with measurable outcomes and success criteria
Identify long-term roadmap themes and sequencing priorities
Ensure that the Program roadmap is responsive to feedback from stakeholders and development team as well as regulatory, compliance, and policy alignment
Portfolio Representation & Prioritization
Prepare and present Program roadmap proposals for portfolio review
Review including stakeholder and development team feedback as well as regulatory, compliance, and policy alignment
Justify relative priority using agreed branch criteria (mission impact, urgency, risk, etc.)
Clearly articulate tradeoffs, dependencies, and consequences of delay including
Collaborate with BCBB portfolio manager, Branch Chief, and executive team to shape portfolio decisions including the preparation of documentation to support funding and resource justifications
Stakeholder Engagement
Serve as primary business/stakeholder representative for the Program
Build alignment across leadership, policy, operations, and technical partners
Translate stakeholder needs into clear milestone statements
Manage expectations at the strategic level
Outcome Accountability
What You Will Need:
Education: Ph.D. in Clinical Genomics or similar field
Experience:
5+ years of demonstrated experience leading complex programs or initiatives, ideally in the field of clinical genomics
4 years of experience operating in a portfolio or matrixed environment
5+ years leadership experience managing scientific or technical teams
Knowledge and Abilities
Understanding of portfolio management principles
Working knowledge of Agile delivery frameworks
Knowledge of systems involving complex information and data flows and interdependencies
Knowledge of breaking down large initiatives into smaller milestones and sequencing them for greatest value delivery
Knowledge of Earned Value Management
Able to develop productive team relationships in a hybrid remote and in person setting
Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred
What Would Be Nice To Have:
Program management certification (PgMP, MSP, or equivalent)
Experience working with Agile product organizations
Experience with programs that involve data lakes or centralized, scalable data repositories
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
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