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Human Genomics Program Lead - Software

Apply Job ID 36887 Date posted 02/27/2026

Job Family:

Software Development & Support (Digital)


Travel Required:

Up to 10%


Clearance Required:

Ability to Obtain Public Trust

The Program Lead is accountable for defining, shaping, and advancing strategic outcomes for our Human Genomics Program’s software products within the NIH NIAID Bioinformatics and Computational Biosciences Branch (BCBB) portfolio. This role works with our BCBB federal leadership, our intramural research Principal Investigator (PI) stakeholders and within our Science Support and Software Development groups to analyze, propose, and track Program roadmap milestones. The role ensures that roadmap milestones align with BCBB and stakeholder priorities and team capabilities. The role reports on Program progress and proposes resources needed to accomplish proposed milestones.

What You Will Do:

  • Human Genomics Program Strategic Direction & Vision

    • Define and maintain a clear Program vision aligned to NIAID and BCBB objectives

    • Articulate roadmap milestones with measurable outcomes and success criteria

    • Identify long-term roadmap themes and sequencing priorities

    • Ensure that the Program roadmap is responsive to feedback from stakeholders and development team as well as regulatory, compliance, and policy alignment

  • Portfolio Representation & Prioritization

    • Prepare and present Program roadmap proposals for portfolio review

    • Review including stakeholder and development team feedback as well as regulatory, compliance, and policy alignment

    • Justify relative priority using agreed branch criteria (mission impact, urgency, risk, etc.)

    • Clearly articulate tradeoffs, dependencies, and consequences of delay including

    • Collaborate with BCBB portfolio manager, Branch Chief, and executive team to shape portfolio decisions including the preparation of documentation to support funding and resource justifications

  • Stakeholder Engagement

    • Serve as primary business/stakeholder representative for the Program

    • Build alignment across leadership, policy, operations, and technical partners

    • Translate stakeholder needs into clear milestone statements

    • Manage expectations at the strategic level

    • Outcome Accountability


What You Will Need:

  • Education: Ph.D. in Clinical Genomics or similar field

  • Experience:

    • 5+ years of demonstrated experience leading complex programs or initiatives, ideally in the field of clinical genomics

    • 4 years of experience operating in a portfolio or matrixed environment

    • 5+ years leadership experience managing scientific or technical teams

  • Knowledge and Abilities

    • Understanding of portfolio management principles

    • Working knowledge of Agile delivery frameworks

    • Knowledge of systems involving complex information and data flows and interdependencies

    • Knowledge of breaking down large initiatives into smaller milestones and sequencing them for greatest value delivery

    • Knowledge of Earned Value Management

    • Able to develop productive team relationships in a hybrid remote and in person setting

    • Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred


What Would Be Nice To Have:

  • Program management certification (PgMP, MSP, or equivalent)

  • Experience working with Agile product organizations

  • Experience with programs that involve data lakes or centralized, scalable data repositories

The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.


What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

  • Medical, Rx, Dental & Vision Insurance

  • Personal and Family Sick Time & Company Paid Holidays

  • Parental Leave

  • 401(k) Retirement Plan

  • Group Term Life and Travel Assistance

  • Voluntary Life and AD&D Insurance

  • Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

  • Transit and Parking Commuter Benefits

  • Short-Term & Long-Term Disability

  • Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

  • Employee Referral Program

  • Corporate Sponsored Events & Community Outreach

  • Care.com annual membership

  • Employee Assistance Program

  • Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

  • Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com.  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

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Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

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